Anti- Plasminogen Monoclonal Antibody (MC2B8) Inhibites Angiogenesis

اثر آنتی بادی های منوکلونال ضد پلاسمینوژن انسانی بر فعال شدن گلو-پلاسمینوژن انسانی بوسیله فعال کننده های پلاسمینوژن

Background: Human plasminogen is a plasma glycoprotein synthesized mainly in the liver. Conversion of plasminogen to plasmin by plasminogen activators is a key event in the fibrinolytic system. In this study, we investigated the effects of two anti-human plasminogen monoclonal antibodies, A1D12 and MC2B8 on Glu-plasminogen activation in presence of u-PA, t-PA and streptokinase. Methods: Produci...

Anti-Gb3 Monoclonal Antibody Inhibits Angiogenesis and Tumor Development

Inhibiting the growth of tumor vasculature represents one of the relevant strategies against tumor progression. Between all the different pro-angiogenic molecular targets, plasma membrane glycosphingolipids have been under-investigated. In this present study, we explore the anti-angiogenic therapeutic advantage of a tumor immunotherapy targeting the globotriaosylceramide Gb3. In this purpose, a...

Development of a Novel Inhibitory Chimeric Anti-HER2 Monoclonal Antibody

Mouse Anti-Tetracycline Monoclonal Antibody

Product Overview: Mouse monoclonal antibody to tetracycline. Immunogen: Tetracycline-KLH Conjugate Clone: K88Y88 Host animal: Mouse Source: Mouse Ascites Purity: Protein A Affinity Chromatography. Buffer: 0.01 moL/L pH 7.4 Phosphate Buffer Solution. Protein Content: 1 mg/mL Appearance: Clear Colorless Solution Introduction: Tetracycline is a broad-spectrum polyketide antibiotic produced by the ...

پتانسیل آنتی‌پلاسمینوژن منوکلونال آنتی‌بادی در دستکاری دو سیستم فیبرینولیز و آنژیوژنز

Background: Plasminogen has a central role in fibrinolyrtic system can activate through various activators (PAs) to its active form plasmin and perfoem its vital function that is fibrin clot lysis. Furthermore the fibrinolyrtic system plays a major role in angiogenesis. The fibrinolyrtic system activation control cell migration and invasion. In addition to this, plasmin regulates tumor growth. ...